NEUROTECHNOLOGY RESEARCH, DEVELOPMENT, AND ENHANCEMENT

NEUROTECHNOLOGY RESEARCH, DEVELOPMENT, AND ENHANCEMENTRELEASE DATE: October 08, 2003PA NUMBER: PA-04-006

• Microfluidic systems for in-vivo spatial and temporal controlled delivery of neurotransmitters and other biomoleculeso
• Proteome analysis arrays, proteome data storage and analysis of proteome data from the nervous systemo
• Genetic approaches to study structure or function of neural circuits in animal modelso
• Biosensors that would be selectively activated by neurochemicals, such as particular neurotransmitters or pharmacological compoundso
• Delivery systems for exogenous agents such as drugs, gene transfer vectors, and cells
• Non-invasive methods for in-vivo tracking of implanted cellso
• Tools for real-time analysis of neurophysiological eventso
• Tools for data mining for genetic discovery and functional insights into genomics and proteomics of the nervous systemo
• Nanocrystals or quantum dots covalently bonded to neural receptor ligands
• Probes of brain gene expression that can be imaged non-invasively (e.g., with magnetic resonance or near infrared optical imaging)o
• Genetic approaches to manipulate or monitor synaptic activity
• Microelectromechanical system (MEMS) devices used for monitoring neuron function in slice and culture preparations
• Amplifiers that are small and light enough to be worn by mice for recording neural activity from many neurons
• Tools, technologies and algorithms for neuroprosthesis development
• Tools to enhance visualization of specific brain markers
• New methods to study neural connectivity in living or post mortem brain, especially human brain
• Improved electrodes, microcomputer interfaces, and microcircuitry for chronic implantation, monitoring of neural activity, and promoting efferent function
• Dynamic monitors of intracranial pressure and cerebral spinal fluid composition (particularly important in following disease progression or recovery from brain injury)
• Devices for non-invasive diagnosis and precise identification of pathogens involved in central and peripheral neural infectious diseases
• Tools for relatively non-invasive ways to assess damage and monitor function in regions of injured or diseased brain tissue
• Non-invasive optical imaging instruments
• Technologies for detection, intervention, and prevention of acute, adverse neurological events
• Tools for early-warning detection of imminent seizure activity; application of targeted treatment to abort seizures
• Technologies to facilitate high-throughput analysis of behavior
• Tools for therapeutic electrical stimulation for rehabilitation following stroke, trauma or other events or disorders that disrupt normal function of the nervous system
• Telemetry devices small and light enough to be worn by mice for transmitting data (e.g., electrophysiological data) during behavior
• Software to translate neuroimaging data from one data format into anothero Algorithms that use shape analysis approaches to understand human neuroimaging data
• Computational approaches to analyzing video data (like those used in behavioral research)
• Computational approaches and improved paradigms for analysis of kinematic data