Tuesday, March 13, 2007



  • Microfluidic systems for in-vivo spatial and temporal controlled delivery of neurotransmitters and other biomoleculeso
  • Proteome analysis arrays, proteome data storage and analysis of proteome data from the nervous systemo
  • Genetic approaches to study structure or function of neural circuits in animal modelso
  • Biosensors that would be selectively activated by neurochemicals, such as particular neurotransmitters or pharmacological compoundso
  • Delivery systems for exogenous agents such as drugs, gene transfer vectors, and cells
  • Non-invasive methods for in-vivo tracking of implanted cellso
  • Tools for real-time analysis of neurophysiological eventso
  • Tools for data mining for genetic discovery and functional insights into genomics and proteomics of the nervous systemo
  • Nanocrystals or quantum dots covalently bonded to neural receptor ligands
  • Probes of brain gene expression that can be imaged non-invasively (e.g., with magnetic resonance or near infrared optical imaging)o
  • Genetic approaches to manipulate or monitor synaptic activity
  • Microelectromechanical system (MEMS) devices used for monitoring neuron function in slice and culture preparations
  • Amplifiers that are small and light enough to be worn by mice for recording neural activity from many neurons
  • Tools, technologies and algorithms for neuroprosthesis development
  • Tools to enhance visualization of specific brain markers
  • New methods to study neural connectivity in living or post mortem brain, especially human brain
  • Improved electrodes, microcomputer interfaces, and microcircuitry for chronic implantation, monitoring of neural activity, and promoting efferent function
  • Dynamic monitors of intracranial pressure and cerebral spinal fluid composition (particularly important in following disease progression or recovery from brain injury)
  • Devices for non-invasive diagnosis and precise identification of pathogens involved in central and peripheral neural infectious diseases
  • Tools for relatively non-invasive ways to assess damage and monitor function in regions of injured or diseased brain tissue
  • Non-invasive optical imaging instruments
  • Technologies for detection, intervention, and prevention of acute, adverse neurological events
  • Tools for early-warning detection of imminent seizure activity; application of targeted treatment to abort seizures
  • Technologies to facilitate high-throughput analysis of behavior
  • Tools for therapeutic electrical stimulation for rehabilitation following stroke, trauma or other events or disorders that disrupt normal function of the nervous system
  • Telemetry devices small and light enough to be worn by mice for transmitting data (e.g., electrophysiological data) during behavior
  • Software to translate neuroimaging data from one data format into anothero Algorithms that use shape analysis approaches to understand human neuroimaging data
  • Computational approaches to analyzing video data (like those used in behavioral research)
  • Computational approaches and improved paradigms for analysis of kinematic data

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